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Iqgap3-Ras axis drives stem cell proliferation in the stomach

To cite: Sundar R, Liu DH, Hutchins GG, et al. Gut 2021;70:1833-1846.

Read the full article here: link
Objective: Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus.

Conclusions: IQGAP3 is a major regulator of stomach epithelial tissue homoeostasis and repair. The upregulation of IQGAP3 in gastric cancer suggests that IQGAP3 plays an important role in cancer cell proliferation.

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